反应详情

温度

140 °C

To a 20 mL microwave reaction vial with a micro magnetic stir bar, were added 0.297 g of 2-amino-5-nitrobenzophenone, 0.186 g of thiourea and 3.0 mL of DMSO. Then the vial was sealed and heated with microwave at 140° C. for 20 hours. Two layers of liquid formed with brown liquid on the top and a dark brown gel like layer at the bottom. The reaction mixture was extracted with EtOAc and purified on column chromatography using hexane/EtOAc (5:1 to 4:1) as eluent, and 0.122 g of 4-phenyl-6-nitro-quinazoline was obtained, in a yield of 39.7%.

1. customTo a 20 mL microwave reaction vial with a micro magnetic stir bar
2. customThen the vial was sealed
3. customTwo layers of liquid formed with brown liquid on the top
4. extractionThe reaction mixture was extracted with EtOAc
5. custompurified on column chromatography