反应详情

温度

140 °C

To a 20 mL microwave reaction vial with a micro magnetic stir bar, were added 0.284 g of 2-amino-4-methylbenzophenone, 0.208 g of thiourea and 3 mL of DMSO. Then the vial was sealed and heated with microwave at 140° C. for 20 hours to form an orange liquid. The reaction mixture was treated in a similar method via column chromatography with hexane/EtOAc (6:1) as eluent to afford 0.293 g of 4-phenyl-7-methyl-quinazoline, in a yield of 99.0%.

1. customTo a 20 mL microwave reaction vial with a micro magnetic stir bar
2. customThen the vial was sealed
3. customto form an orange liquid