Hydrogen Bromide → HCID 10775914, compound

Participants

Reaction Steps

Compound 7 (3 g, 8.97 mmol) was refluxed for 18 h in a 20 mL solution consisting of a 1:1 mixture of HBr and acetic acid. The reaction mixture was neutralized by adding saturated aqueous NaHCO3. The subsequent mixture was then extracted with ethyl acetate and the organic layer was further washed with brine, water and dried over Na2SO4. After removing the solvent in vacuo, the brown, viscous residue was purified by column chromatography (5-20% ethyl acetate/hexane) to yield 8 (1.6 g, 77%) as a yellow solid.

Provenance & Evidence