Chloroform → HCID 46193619, compound

Participants

Reaction Conditions

Reaction Steps

Compound 8 (100 mg, 0.431 mmol) and aluminum trichloride (287 mg, 2.15 mmol) were suspended in 5 mL of carbon disulfide at rt. Chloroform (6 mL) was added to the suspension and the reaction mixture was warmed to 50° C. in a water-bath. Isovaleryl chloride (259 mg, 2.15 mmol) was added dropwise and the reaction was stirred for 2 h at 50° C. After removing solvent in vacuo, and the crude reaction mixture was purified by column chromatography (1-5% ethyl acetate/hexane) to yield 3 (30 mg, 17%) as a white solid.

Provenance & Evidence