HCID 68748561, compound → (1S,2R)-2-(2-((3-(1H-Benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-4,4,6-trifluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-ol

HRID 919197Notes

Reaction equation

HRID 919197 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13]([CH3:34])[C:14](=O)[CH2:15][C@@:16]1([OH:32])[CH2:25][C:24]([F:27])([F:26])[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([F:28])[CH:22]=2)[C@@H:17]1[CH:29]([CH3:31])[CH3:30].N1C2C=CC=CC=2N=C1CCCN(C)CCC1(O)C([2H])([2H])C([2H])([2H])C2C(=CC=C(F)C=2)C1C(C)C>>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13]([CH3:34])[CH2:14][CH2:15][C@@:16]1([OH:32])[CH2:25][C:24]([F:27])([F:26])[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([F:28])[CH:22]=2)[C@@H:17]1[CH:29]([CH3:31])[CH3:30]

Participants

3

Reactant 2

HCID 68748561HCID 68748561, compoundHCID 86720677HCID 86720677, compound

Product 1

HCID 68750604(1S,2R)-2-(2-((3-(1H-Benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-4,4,6-trifluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-ol

Procedure

35d is prepared from 17d in a manner analogous to that of Example 2, step 2 for 35b.

Sources & evidence

ORD record
ord-cecabc35a4044974973970b90f5520cd
Source dataset
uspto-grants-2016_03
Patent number
US09273009B2

Reaction notes

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