HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Cyclobutylpiperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-cyclobutylpiperazine-1-carboxylate | HCID 57423951 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Cyclobutylpiperazine hydrochloride | HCID 23090379 | 82% |
Reaction Steps
To the mixture of tert-butyl 4-cyclobutylpiperazine-1-carboxylate (48 g, 200 mmol) in MeOH (100 mL) was added 2.0 M HCl in MeOH (400 mL) carefully at 0° C. The mixture was stirred at rt for 5 h, concentrated under reduced pressure to afford the desired compound 1-cyclobutylpiperazine hydrochloride (35 g, 82%) [LCMS: Rt=0.94 min, m/z 141.3 (M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273026B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-cb5530360db94bcda918e54bc1873b5b |
| Source note | uspto-grants-2016_03 |