HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1,3)Dioxolan-2-ylmethyl-1H-pyrazole-4-boronic acid, pinacol ester → 3-Amino-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)-pyrazine-2-carboxylic acid pyridin-4-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1,3)Dioxolan-2-ylmethyl-1H-pyrazole-4-boronic acid, pinacol ester | HCID 17998927 | — |
| Reactant | 3-Amino-6-bromo-N-4-pyridinyl-2-pyrazinecarboxamide | HCID 86719154 | — |
| Product | 3-Amino-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)-pyrazine-2-carboxylic acid pyridin-4-ylamide | HCID 71061192 | — |
Reaction Steps
The reaction of 3-amino-6-bromo-pyrazine-2-carboxylic acid pyridin-4-ylamide (synthesis described for “A10”) with 1-[1,3]dioxolan-2-ylmethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole gives the compound “A12”
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-b4d29b2321d84179a0c095cfd7864057 |
| Source note | uspto-grants-2016_03 |