HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-{[5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl]methyl}piperidine → 3-Amino-6-(5-piperidin-1-ylmethyl-thiophen-2-yl)-pyrazine-2-carboxylic acid pyridin-4-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-{[5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl]methyl}piperidine | HCID 46739745 | — |
| Reactant | 3-Amino-6-bromo-N-4-pyridinyl-2-pyrazinecarboxamide | HCID 86719154 | — |
| Product | 3-Amino-6-(5-piperidin-1-ylmethyl-thiophen-2-yl)-pyrazine-2-carboxylic acid pyridin-4-ylamide | HCID 71062547 | — |
Reaction Steps
The reaction of 3-amino-6-bromo-pyrazine-2-carboxylic acid pyridin-4-ylamide (synthesis described for “A10”) with 1-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-thiophen-2-ylmethyl]-piperidine gives the compound “A13”;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-f5f8be90e4cd4cf8820b10e6c4192f1a |
| Source note | uspto-grants-2016_03 |