HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)pyrrolidine → 3-Amino-6-(5-pyrrolidin-1-ylmethyl-thiophen-2-yl)-pyrazine-2-carboxylic acid pyridin-4-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)pyrrolidine | HCID 46739746 | — |
| Reactant | 3-Amino-6-bromo-N-4-pyridinyl-2-pyrazinecarboxamide | HCID 86719154 | — |
| Product | 3-Amino-6-(5-pyrrolidin-1-ylmethyl-thiophen-2-yl)-pyrazine-2-carboxylic acid pyridin-4-ylamide | HCID 71061112 | — |
Reaction Steps
The reaction of 3-amino-6-bromo-pyrazine-2-carboxylic acid pyridin-4-ylamide (synthesis described for “A10”) with 1-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-thiophen-2-ylmethyl]-pyrrolidine gives the compound “A14”;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-25ef332c7b2c40809243f12738345680 |
| Source note | uspto-grants-2016_03 |