HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine → 2-Amino-N-(3-methyl-pyridin-4-yl)-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine | HCID 46739046 | — |
| Reactant | 2-amino-5-bromo-N-(3-methylpyridin-4-yl)nicotinamide | HCID 63670385 | — |
| Product | 2-Amino-N-(3-methyl-pyridin-4-yl)-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-nicotinamide | HCID 71060861 | — |
Reaction Steps
Reaction of 2-amino-5-bromo-N-(3-methyl-pyridin-4-yl)-nicotinamide with 5-(4-morpholinylmethyl)thiophene-2-boronic acid pinacol ester gives the compound “A21”; HPLC/MS: 0.97 min, [M+H]=410;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-64a1e91601304ae2a9656c293c0f3c37 |
| Source note | uspto-grants-2016_03 |