HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Methoxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester → 2-Amino-5-[1-(2-methoxy-ethyl)-1H-pyrazol-4-yl]-N-(3-methyl-pyridin-4-yl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Methoxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester | HCID 11230491 | — |
| Reactant | 2-amino-5-bromo-N-(3-methylpyridin-4-yl)nicotinamide | HCID 63670385 | — |
| Product | 2-Amino-5-[1-(2-methoxy-ethyl)-1H-pyrazol-4-yl]-N-(3-methyl-pyridin-4-yl)-nicotinamide | HCID 71061119 | — |
Reaction Steps
Reaction of 2-amino-5-bromo-N-(3-methyl-pyridin-4-yl)-nicotinamide with 1-(2-methoxy-ethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole gives the compound “A22”; HPLC/MS: 1.07 min, [M+H]=353;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-452bd97fadcb4e1581653780e91592b1 |
| Source note | uspto-grants-2016_03 |