4-Aminopyrimidine → 2-amino-5-bromo-N-pyrimidin-4-yl-pyridine-3-carboxamide

HRID 919227Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][C:5]([Br:11])=[CH:4][N:3]=1.[N:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[N:14][CH:13]=1.NC1N=CC(C2SC(CN3CCCCC3)=CC=2)=CC=1C(NC1C=CN=CC=1)=O>>[NH2:1][C:2]1[C:7]([C:8]([NH:18][C:15]2[CH:16]=[CH:17][N:12]=[CH:13][N:14]=2)=[O:10])=[CH:6][C:5]([Br:11])=[CH:4][N:3]=1

Participants

Reactant 3

HCID 689584-Aminopyrimidine

HCID 7374452-Amino-5-bromonicotinic acid

HCID 71061295HCID 71061295, compound

Product 1

HCID 710611572-amino-5-bromo-N-pyrimidin-4-yl-pyridine-3-carboxamide

Procedure

6.1 Reaction of 2-amino-5-bromo-pyridine-3-carboxylic acid with pyrimidin-4-amine according to the synthesis described for “A1” step 1, gives 2-amino-5-bromo-N-pyrimidin-4-yl-pyridine-3-carboxamide.

Sources & evidence

ORD record: ord-e32e5e2c0a884bbb9bc25842561e1ee1
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09273029B2

Reaction notes

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