HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine → 2-Amino-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-N-pyrimidin-4-yl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine | HCID 46739046 | — |
| Reactant | 2-amino-5-bromo-N-pyrimidin-4-yl-pyridine-3-carboxamide | HCID 71061157 | — |
| Reactant | HCID 71061295 | HCID 71061295 | — |
| Product | 2-Amino-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-N-pyrimidin-4-yl-nicotinamide | HCID 71061082 | — |
Reaction Steps
6.2 “A27” is prepared from 2-amino-5-bromo-N-pyrimidin-4-yl-pyridine-3-carboxamide and 5-(4-morpholinylmethyl)thiophene-2-boronic acid pinacol ester according to step 2 of the synthesis of “A1”;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-5c46b64175674a499f2ead956f75e2f8 |
| Source note | uspto-grants-2016_03 |