2-Amino-5-bromonicotinic acid → 2-Amino-5-bromo-N-furo[3,2-b]pyridin-7-yl-pyridine-3-carboxamide

HRID 919229Notes

Reaction equation

HRID 919229 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][C:5]([Br:11])=[CH:4][N:3]=1.[O:12]1[C:20]2[C:15](=[N:16][CH:17]=[CH:18][C:19]=2[NH2:21])[CH:14]=[CH:13]1.NC1N=CC(C2SC(CN3CCCCC3)=CC=2)=CC=1C(NC1C=CN=CC=1)=O>>[NH2:1][C:2]1[C:7]([C:8]([NH:21][C:19]2[CH:18]=[CH:17][N:16]=[C:15]3[CH:14]=[CH:13][O:12][C:20]=23)=[O:10])=[CH:6][C:5]([Br:11])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 7374452-Amino-5-bromonicotinic acidHCID 46737938Furo[3,2-b]pyridin-7-amineHCID 71061295HCID 71061295, compound

Product 1

HCID 710609512-Amino-5-bromo-N-furo[3,2-b]pyridin-7-yl-pyridine-3-carboxamide

Procedure

7.1 Reaction of 2-amino-5-bromo-pyridine-3-carboxylic acid with furo[3,2-b]pyridin-7-amine according to the synthesis described for “A1” step 1, gives 2-Amino-5-bromo-N-furo[3,2-b]pyridin-7-yl-pyridine-3-carboxamide.

Sources & evidence

ORD record
ord-251198b86ce04e169ca66f3ba185a072
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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