4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine → 2-Amino-N-furo[3,2-b]pyridin-7-yl-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-nicotinamide

HRID 919230Notes

Reaction equation

HRID 919230 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]3[CH:17]=[CH:18][O:19][C:12]=23)=[O:9])=[CH:6][C:5](Br)=[CH:4][N:3]=1.[N:21]1([CH2:27][C:28]2[S:32][C:31](B3OC(C)(C)C(C)(C)O3)=[CH:30][CH:29]=2)[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>>[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:31]2[S:32][C:28]([CH2:27][N:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)=[CH:29][CH:30]=2)=[CH:6][C:7]=1[C:8]([NH:10][C:11]1[CH:16]=[CH:15][N:14]=[C:13]2[CH:17]=[CH:18][O:19][C:12]=12)=[O:9]

Participants

3

Reactant 2

HCID 467390464-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholineHCID 710609512-Amino-5-bromo-N-furo[3,2-b]pyridin-7-yl-pyridine-3-carboxamide

Product 1

HCID 710612392-Amino-N-furo[3,2-b]pyridin-7-yl-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-nicotinamide

Procedure

Reaction of 2-amino-5-bromo-N-furo[3,2-b]pyridin-7-yl-pyridine-3-carboxamide (synthesis described above) with 5-(4-morpholinylmethyl)thiophene-2-boronic acid pinacol ester gives the compound “A29”;

Workup

  1. customgives the compound “A29”

Sources & evidence

ORD record
ord-9bce0c1db6334829b9ddc4e12632c86a
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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