HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine → 2-Amino-N-(3-chloro-pyridin-4-yl)-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine | HCID 46739046 | — |
| Reactant | 2-amino-5-bromo-N-(3-chloro-4-pyridyl)pyridine-3-carboxamide | HCID 71060805 | — |
| Product | 2-Amino-N-(3-chloro-pyridin-4-yl)-5-(5-morpholin-4-ylmethyl-thiophen-2-yl)-nicotinamide | HCID 71061259 | — |
Reaction Steps
Reaction of 2-amino-5-bromo-N-(3-chloro-4-pyridyl)pyridine-3-carboxamide with 5-(4-morpholinylmethyl)thiophene-2-boronic acid pinacol ester gives the compound “A33”; HPLC/MS: 1.25 min, [M+H]=343;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-4290fb889db54aa2adaf297c7e78d644 |
| Source note | uspto-grants-2016_03 |