HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine → Methyl 4-[[2-amino-5-[5-(morpholinomethyl)-2-thienyl]pyridine-3-carbonyl]amino]pyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine | HCID 46739046 | — |
| Reactant | Methyl 4-[(2-amino-5-bromo-pyridine-3-carbonyl)amino]pyridine-3-carboxylate | HCID 71061375 | — |
| Product | Methyl 4-[[2-amino-5-[5-(morpholinomethyl)-2-thienyl]pyridine-3-carbonyl]amino]pyridine-3-carboxylate | HCID 71060833 | — |
Reaction Steps
Reaction of methyl 4-[(2-amino-5-bromo-pyridine-3-carbonyl)amino]pyridine-3-carboxylate with 5-(4-morpholinylmethyl)thiophene-2-boronic acid pinacol ester gives compound “A35”; HPLC/MS: 1.36 min, [M+H]=454;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273029B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-d86ea79b5ee040b2b6d8d2441674332f |
| Source note | uspto-grants-2016_03 |