4-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine → HCID 71061426, compound

HRID 919236Notes

Reaction equation

HRID 919236 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([NH:11][C:12]([C:14]2[C:15]([NH2:21])=[N:16][CH:17]=[C:18](Br)[CH:19]=2)=[O:13])[CH:8]=[CH:7][N:6]=1)(=[O:3])[CH3:2].[N:22]1([CH2:28][C:29]2[S:33][C:32](B3OC(C)(C)C(C)(C)O3)=[CH:31][CH:30]=2)[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([NH:11][C:12](=[O:13])[C:14]2[CH:19]=[C:18]([C:32]3[S:33][C:29]([CH2:28][N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)=[CH:30][CH:31]=3)[CH:17]=[N:16][C:15]=2[NH2:21])[CH:8]=[CH:7][N:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 467390464-((5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholineHCID 71060858HCID 71060858, compound

Product 1

HCID 71061426HCID 71061426, compound

Procedure

Reaction of N-(2-acetamido-4-pyridyl)-2-amino-5-bromo-pyridine-3-carboxamide with 5-(4-morpholinylmethyl)thiophene-2-boronic acid pinacol ester gives the compound “A36”; HPLC/MS: 1.14 min, [M+H]=453;

Workup

  1. customgives the compound “A36”
  2. custom1.14 min, [M+H]=453

Sources & evidence

ORD record
ord-094100d3d6764b2c8a4e9b50b761b838
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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