3-(Methoxycarbonyl)benzeneboronic acid → HCID 71060964, compound

HRID 919237Notes

Reaction equation

HRID 919237 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7](B(O)O)[CH:8]=[CH:9][CH:10]=1)=[O:4].[NH2:14][C:15]1[N:29]=[CH:28][C:27](Br)=[CH:26][C:16]=1[C:17]([NH:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)=[O:18].NC1N=CC(C2SC(CN3CCCCC3)=CC=2)=CC=1C(NC1C=CN=CC=1)=O>>[NH2:14][C:15]1[N:29]=[CH:28][C:27]([C:7]2[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=2)[C:3]([O:2][CH3:1])=[O:4])=[CH:26][C:16]=1[C:17](=[O:18])[NH:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 27347143-(Methoxycarbonyl)benzeneboronic acidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamideHCID 71061295HCID 71061295, compound

Product 1

HCID 71060964HCID 71060964, compound

Procedure

(3-Methoxycarbonylphenyl)boronic acid and 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide are reacted analogously to “A1” step 2 to give methyl 3-[6-amino-5-(4-pyridylcarbamoyl)-3-pyridyl]benzoate.

Sources & evidence

ORD record
ord-fb73f91214e24cd7960097ad43ece33f
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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