HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 919242Generated: October 27, 2026
Water → 2-Amino-5-(3-hydroxymethyl-phenyl)-N-pyridin-4-yl-nicotinamide
https://huagongshe.com/reaction/919242
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 2-amino-5-bromo-N-(pyridin-4-yl)nicotinamide | HCID 62155416 | — |
| Catalyst | HCID 178477754 | HCID 178477754 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Amino-5-(3-hydroxymethyl-phenyl)-N-pyridin-4-yl-nicotinamide | HCID 71061031 | — |
Reaction Steps
100 mg of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide and 62.2 mg 3-hydroxy-methyl)-benzeneboronic acid are dissolved in 4 ml of DMF. 90.4 mg Na2CO3 and 1 ml water are added under argon. 13.9 mg of [1,1-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) are added. The mixture is stirred for 14 h at 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09273029B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-dbbd538c1f8c43d28b3a2ce2852a0936 |
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| Source note | uspto-grants-2016_03 |
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