2-(Hydroxymethyl)phenylboronic Acid → HCID 71080401, compound

HRID 919243Notes

Reaction equation

HRID 919243 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].[OH:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1B(O)O>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH2:19][OH:18])=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 43742622-(Hydroxymethyl)phenylboronic AcidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71080401HCID 71080401, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 2-(hydroxymethyl)-benzeneboronic acid gives “A63”; method 1: HPLC/MS: 1.07 min, [M+H]=321;

Workup

  1. customgives “A63”
  2. custom1.07 min, [M+H]=321

Sources & evidence

ORD record
ord-37a655e4fe2c45ba84534daa1ac31790
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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