(4-Aminophenyl)boronic acid hydrochloride → HCID 86719155, compound

HRID 919245Notes

Reaction equation

HRID 919245 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].Cl.[NH2:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:23]2[CH:24]=[CH:25][C:20]([NH2:19])=[CH:21][CH:22]=2)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 2734614(4-Aminophenyl)boronic acid hydrochlorideHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 86719155HCID 86719155, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 4-aminophenyl-boronic acid hydrochloride gives “A65”; method 2: HPLC/MS: 1.53 min, [M+H]=306;

Workup

  1. customgives “A65”
  2. custom1.53 min, [M+H]=306

Sources & evidence

ORD record
ord-c190f9a874af426e90e4ae6dc49f85d4
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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