2-Formylphenylboronic acid → HCID 86719156, compound

HRID 919246Notes

Reaction equation

HRID 919246 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].[CH:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1B(O)O)=[O:19]>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:18]=[O:19])=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 2921892-Formylphenylboronic acidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 86719156HCID 86719156, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 2-formylphenyl-boronic acid gives “A66”; method 1: HPLC/MS: 1.23 min, [M+H]=319;

Workup

  1. customgives “A66”
  2. custom1.23 min, [M+H]=319

Sources & evidence

ORD record
ord-c91670ff6e2b49fc83989b01d0fbd520
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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