4-(Hydroxymethyl)benzeneboronic acid → HCID 71062705, compound

HRID 919248Notes

Reaction equation

HRID 919248 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].[OH:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:23]2[CH:24]=[CH:25][C:20]([CH2:19][OH:18])=[CH:21][CH:22]=2)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 27347064-(Hydroxymethyl)benzeneboronic acidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71062705HCID 71062705, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 4-(hydroxymethyl)-phenylboronic acid; method 1: HPLC/MS: 1.12 min, [M+H]=321;

Workup

  1. custom1.12 min, [M+H]=321

Sources & evidence

ORD record
ord-7210557627e847bc9e667a08a862d2d5
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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