4-Ethoxycarbonylphenylboronic acid → HCID 71061208, compound

HRID 919251Notes

Reaction equation

HRID 919251 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].[CH2:18]([O:20][C:21]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)=[O:22])[CH3:19]>>[CH2:18]([O:20][C:21](=[O:22])[C:23]1[CH:28]=[CH:27][C:26]([C:14]2[CH:15]=[N:16][C:2]([NH2:1])=[C:3]([C:4](=[O:5])[NH:6][C:7]3[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=3)[CH:13]=2)=[CH:25][CH:24]=1)[CH3:19]

Participants

3

Reactant 2

HCID 27343504-Ethoxycarbonylphenylboronic acidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71061208HCID 71061208, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 4-ethoxycarbonyl-phenylboronic acid gives “A71”; method 1: HPLC/MS: 1.46 min, [M+H]=363;

Workup

  1. customgives “A71”
  2. custom1.46 min, [M+H]=363

Sources & evidence

ORD record
ord-9da6ba597b2a48cdade8232293d5891d
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

Loading…