2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 71060978, compound

HRID 919253Notes

Reaction equation

HRID 919253 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].CC1(C)C(C)(C)OB([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[OH:32])O1>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[OH:32])=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 27346222-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71060978HCID 71060978, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol gives “A73”; method 1: HPLC/MS: 1.16 min, [M+H]=307;

Workup

  1. customgives “A73”
  2. custom1.16 min, [M+H]=307

Sources & evidence

ORD record
ord-ec9ca257602149a1afd3efb05da32b06
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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