3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide → HCID 71080374, compound

HRID 919258Notes

Reaction equation

HRID 919258 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].B1([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([S:33]([NH2:36])(=[O:35])=[O:34])[CH:28]=2)OC(C)(C)C(C)(C)O1>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([S:33](=[O:35])(=[O:34])[NH2:36])[CH:28]=2)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 164142303-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamideHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71080374HCID 71080374, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with benzenesulfon-amide-3-boronic acid pinacol ester gives “A78”; method 1: HPLC/MS: 1.13 min, [M+H]=370;

Workup

  1. customgives “A78”
  2. custom1.13 min, [M+H]=370

Sources & evidence

ORD record
ord-cc8fb12d71254822b8fa62a351e0e9d2
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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