2-amino-5-bromo-N-(pyridin-4-yl)nicotinamide → HCID 71061133, compound

HRID 919259Notes

Reaction equation

HRID 919259 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].CC1(C)C(C)(C)OB([C:26]2[CH:27]=[C:28]([S:32]([N:35]3[CH2:40][CH2:39][CH:38]([OH:41])[CH2:37][CH2:36]3)(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=2)O1>>[NH2:1][C:2]1[N:16]=[CH:15][C:14]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([S:32]([N:35]3[CH2:40][CH2:39][CH:38]([OH:41])[CH2:37][CH2:36]3)(=[O:34])=[O:33])[CH:27]=2)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5]

Participants

3

Reactant 2

HCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamideHCID 71061532HCID 71061532, compound

Product 1

HCID 71061133HCID 71061133, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzenesulfonyl]-piperidin-4-ol gives “A79”; method 1: HPLC/MS: 1.29 min, [M+H]=454;

Workup

  1. customgives “A79”
  2. custom1.29 min, [M+H]=454

Sources & evidence

ORD record
ord-b5f674ade37c445a99790e86c402907b
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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