3-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → HCID 71060843, compound

HRID 919260Notes

Reaction equation

HRID 919260 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].[F:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][C:24]=1[C:25]([O:27][CH3:28])=[O:26]>>[CH3:28][O:27][C:25](=[O:26])[C:24]1[CH:23]=[CH:22][C:21]([C:14]2[CH:15]=[N:16][C:2]([NH2:1])=[C:3]([C:4](=[O:5])[NH:6][C:7]3[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=3)[CH:13]=2)=[CH:20][C:19]=1[F:18]

Participants

3

Reactant 2

HCID 27828183-Fluoro-4-(methoxycarbonyl)benzeneboronic acidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71060843HCID 71060843, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 3-fluoro-4-methoxycarbonyl-phenylboronic acid gives “A80”; method 1: HPLC/MS: 1.48 min, [M+H]=367;

Workup

  1. customgives “A80”
  2. custom1.48 min, [M+H]=367

Sources & evidence

ORD record
ord-0959eafbce404ef580654f2268ac1a1e
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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