tert-Butyl (2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate → HCID 71061178, compound

HRID 919261Notes

Reaction equation

HRID 919261 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].[C:18]([O:22][C:23](=[O:40])[NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1B1OC(C)(C)C(C)(C)O1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23](=[O:40])[NH:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:30]=1[C:14]1[CH:15]=[N:16][C:2]([NH2:1])=[C:3]([C:4](=[O:5])[NH:6][C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)[CH:13]=1)([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 2773231tert-Butyl (2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamateHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71061178HCID 71061178, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with [2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-carbamic acid tert-butyl ester gives “A81”; method 1: HPLC/MS: 1.38 min, [M+H]=406;

Workup

  1. customgives “A81”
  2. custom1.38 min, [M+H]=406

Sources & evidence

ORD record
ord-fd558c140c87477184821feacbac1d00
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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