(3-Boc-aminophenyl)boronic acid → HCID 71060829, compound

HRID 919262Notes

Reaction equation

HRID 919262 reaction equation
[NH2:1][C:2]1[N:16]=[CH:15][C:14](Br)=[CH:13][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:5].[C:18]([NH:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1)([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>>[C:21]([O:20][C:18](=[O:19])[NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:14]2[CH:15]=[N:16][C:2]([NH2:1])=[C:3]([C:4](=[O:5])[NH:6][C:7]3[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=3)[CH:13]=2)[CH:27]=1)([CH3:24])([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 2773228(3-Boc-aminophenyl)boronic acidHCID 621554162-amino-5-bromo-N-(pyridin-4-yl)nicotinamide

Product 1

HCID 71060829HCID 71060829, compound

Procedure

Reaction of 2-amino-5-bromo-N-pyridin-4-yl-nicotinamide with 3-(N-Boc-amino)phenylboronic acid gives “A82”; method 1: HPLC/MS: 1.56 min, [M+H]=406.

Workup

  1. customgives “A82”
  2. custom1.56 min, [M+H]=406

Sources & evidence

ORD record
ord-47f0fb0ad42b42b5aaf5118fd6b2d6a8
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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