N-BOC-ethylenediamine → HCID 71060850, compound

HRID 919273Notes

Reaction equation

HRID 919273 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[C:17](=[O:25])[NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.[C:26]([O:30][C:31](=[O:36])[NH:32][CH2:33][CH2:34][NH2:35])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:31](=[O:36])[NH:32][CH2:33][CH2:34][NH:35][C:12](=[O:13])[C:11]1[CH:15]=[CH:16][C:8]([C:5]2[CH:6]=[N:7][C:2]([NH2:1])=[C:3]([C:17](=[O:25])[NH:18][C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)[CH:4]=2)=[CH:9][CH:10]=1)([CH3:29])([CH3:27])[CH3:28]

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 71061416HCID 71061416, compound

Product 1

HCID 71060850HCID 71060850, compound

Procedure

Reaction of 4-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid with (2-amino-ethyl)-carbamic acid tert-butyl ester gives “A96”; method 1: HPLC/MS: 1.47 min, [M+H]=477;

Workup

  1. customgives “A96”
  2. custom1.47 min, [M+H]=477

Sources & evidence

ORD record
ord-4d1806492fee476fa852a2da95c16744
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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