Ammonia → 2-Amino-5-(3-carbamoyl-phenyl)-N-pyridin-4-yl-nicotinamide

HRID 919276Notes

Reaction equation

HRID 919276 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=2)[C:11]([OH:13])=O)=[CH:4][C:3]=1[C:17](=[O:25])[NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.[NH3:26]>>[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][CH:14]=[C:10]([C:11](=[O:13])[NH2:26])[CH:9]=2)=[CH:4][C:3]=1[C:17]([NH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)=[O:25]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 710607733-[6-Amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid

Product 1

HCID 710626652-Amino-5-(3-carbamoyl-phenyl)-N-pyridin-4-yl-nicotinamide

Procedure

Reaction of 3-[6-amino-5-(pyridin-4-ylcarbamoyl)-pyridin-3-yl]-benzoic acid with ammonia gives “A99”; method 2: HPLC/MS: 1.64 min, [M+H]=334.

Workup

  1. customgives “A99”
  2. custom1.64 min, [M+H]=334

Sources & evidence

ORD record
ord-4a7f833585b84dc1b1121d771de987ab
Source dataset
uspto-grants-2016_03
Patent number
US09273029B2

Reaction notes

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