Methylamine → 4-(Methylamino)-3-nitrobenzoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloro-3-nitrobenzoic acid compound of formula-8 (200 g) and methyl amine (660 ml) was taken into autoclave and heated to 85-90° C. and stirred for 5 hours under pressure of 2.0-2.5 kg. After completion of the reaction, the reaction mixture was cooled to 25-35° C. Quenched the reaction mixture with water and then acidified with hydrochloric acid. Filtered the precipitated solid and then dried to get title compound.

Provenance & Evidence