Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 4-Aminobenzonitrile | HCID 13396 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium chloroacetate | HCID 23665759 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(4-Cyanophenyl)glycine | HCID 817965 | — |
Reaction Steps
Sodium mono chloroacetate (197.42 g), followed by potassium iodide (5 g) and tetrabutyl ammonium bromide (2.5 g) were added to a mixture of 4-aminobenzonitrile (100 g), water (1000 ml) and sodium bicarbonate (42.71 g). The reaction mixture was heated to 85-90° C. and stirred for 24 hours. The reaction mixture was cooled to 25-30° C. and treated with ammonia followed by hydrochloric acid. Filtered the solid, washed with water and then dried to get title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09273030B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-dd24db35014a43cf820de8b964dfd531 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
