HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → ethyl 3-[[2-[[4-[(Z)-N'-hexoxycarbonylcarbamimidoyl]anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate;methanesulfonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | ethyl 3-(2-((4-(N-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate | HCID 6445226 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | ethyl 3-[[2-[[4-[(Z)-N'-hexoxycarbonylcarbamimidoyl]anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate;methanesulfonic acid | HCID 11434065 | — |
Reaction Steps
Methane sulfonic acid (1.5 g) was slowly added to a mixture of Dabigatran etexilate (10 g) and tetrahydrofuran (120 ml) at 25-30° C. and stirred for 5 hours. Filtered the precipitated solid, washed with tetrahydrofuran and then dried to get crystalline form-I of Dabigatran etexilate mesylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273030B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-5c81bf0b8ccd42d1a1cbbc4ca5e87f70 |
| Source note | uspto-grants-2016_03 |