反应详情

温度

60 °C

A mixture of 5-bromopyridin-2-ol (100 mg, 0.57 mmol), methyl 2-bromoacetate (168 mg, 1.1 mmol) and potassium carbonate (238 mg, 1.7 mmol) in acetone (5 mL) was stirred at 60° C. for 3 h. The solution was allowed to cool to room temperature, filtered and the filter cake was washed with acetone (5 mL×2). The filtrate was collected and concentrated under reduced pressure to give the crude product, which was purified by silica gel column chromatography (PE: EA=15:1) to afford the title compound: LC/MS m/z=246.1 [M+H]+

1. temperatureto cool to room temperature
2. filtrationfiltered
3. washthe filter cake was washed with acetone (5 mL×2)
4. customThe filtrate was collected
5. concentrationconcentrated under reduced pressure
6. customto give the crude product, which
7. customwas purified by silica gel column chromatography (PE: EA=15:1)