HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 919300Generated: November 1, 2026
4-Chloro-3-iodopyridin-2-amine → 4-Chloro-3-(methylthio)pyridin-2-amine
https://huagongshe.com/reaction/919300
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-3-iodopyridin-2-amine | HCID 22936596 | — |
| Reactant | Mesna | HCID 23662354 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-Chloro-3-(methylthio)pyridin-2-amine | HCID 90177075 | — |
Reaction Steps
To a solution 4-chloro-3-iodopyridin-2-amine (400 mg, 1.57 mmol), CuI (30 mg, 0.157 mmol) in i-PrOH (3 mL) and glycol (10 mg, 0.157 mmol) was added MeSNa (110 mg, 1.57 mmol). The resulting mixture was allowed to stir at 100° C. for 24 h. The reaction mixture was concentrated and the resulting residue was purified by column chromatography to afford the title compound as oil. LC/MS m/z=175.19 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273033B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-8d29595a5d554f4eaeea9f08677180aa |
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| Source note | uspto-grants-2016_03 |
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