HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 919302Generated: October 30, 2026
N-methyl-2-pyrrolidone → HCID 90177068, compound
https://huagongshe.com/reaction/919302
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 4-Chloro-3-iodopyridin-2-amine | HCID 22936596 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 90177068 | HCID 90177068 | — |
Reaction Steps
To a solution 4-chloro-3-iodopyridin-2-amine (200 mg, 0.79 mmol), Zn(CN)2 (46 mg, 0.39 mmol) in NMP (3 mL) was added Pd(PPh3)4 (136 mg, 0.12 mmol). The resulting mixture was allowed to stir at 95° C. under N2 for overnight. The reaction mixture was purified by column chromatography to afford the title compound as a white solid. LC/MS m/z=153.2 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09273033B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-dead9667bec34e5cbea7081243dd83d0 |
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| Source note | uspto-grants-2016_03 |
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