HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4,5-Dichloro-1,2-phenylenediamine | HCID 79297 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One | HCID 9899148 | 91.5% |
Reaction Steps
To the solution of 4,5-dichloro-benzene-1,2-diamine (25 g, 0.14 mol) in dry DMF (200 mL), was added CDI (23 g, 0.14 mol) as the solid. The reaction solution was stirred at room temperature for 1 hour, then water (500 mL) was added. The precipitated solid was collected by filtration, washed with water, dried thoroughly to afford the titled compound (26.0 g, 90%). The crude product was used in the following reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273034B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-d736183869774be2acd93ff99c6c46df |
| Source note | uspto-grants-2016_03 |