HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → HCID 71736383, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | HCID 89816112 | HCID 89816112 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71736383 | HCID 71736383 | 64% |
Reaction Steps
To a solution of product of step 2 (309 mg, 1.00 mmoles) in DMF (3 mL), (tetrahydro-2H-pyran-4-yl)methanamine (126 mg, 1.10 mmoles), HOBT (202 mg, 1.50 mmoles), EDC.HCl (230 mg, 1.20 mmoles) and N-ethyl morpholine (345 mg, 3.00 mmoles) were added and reaction mixture was stirred at room temperature for 20 hours under nitrogen atmosphere. The reaction mixture was poured into ice cold water, solid separated was filtered, washed with water and dried over P2O5 under vacuum to yield 260 mg of title product as pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273041B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-4ef5c3c93d5a4df98640577d064fed13 |
| Source note | uspto-grants-2016_03 |