HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Bis(trifluoromethyl)phenyl isocyanate → HCID 11363880, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Bis(trifluoromethyl)phenyl isocyanate | HCID 2733314 | — |
| Reactant | 3-(4-Chloro-2-methyl-2H-pyrazol-3-yl)4-methoxy-phenylamine | HCID 23139518 | — |
| Product | HCID 11363880 | HCID 11363880 | 32% |
Reaction Steps
3-(4-Chloro-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine was treated with 3,5-Bis(trifluoromethyl)phenyl isocyanate in a similar manner as described in Example 1.53, providing 21.5 mg (32%) of Compound 82: LCMS m/z (%)=495 (M+H37Cl, 41), 493 (M+H35Cl, 100). 1H NMR (400 MHz, DMSO-d6) δ: 9.58 (s, 1H), 9.18 (s, 1H), 8.31 (s, 2H), 7.80 (s, 1H), 7.79 (s, 1H), 7.79 (dd, J1=8 Hz, J2=4 Hz, 1H), 7.59 (d, J=2 Hz, 1H), 7.36 (d, =8 Hz, 1H), 3.96 (s, 3H), 3.80 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273035B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-39615c5651164d48888d62cc06f0a4d3 |
| Source note | uspto-grants-2016_03 |