Hydrochloric Acid → HCID 118906762, compound

Participants

Reaction Steps

To a solution of test-butyl 3-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)azepane-1-carboxylate (1.4 g, 2.9 mmol) in 1,4-dioxane (15 mL) was added 6 N HCl (2 mL) and the reaction mixture was stirred for 2 h. The reaction mixture was concentrated in vacuo and the resultant residue was dissolved in EtOAc, washed with 10% NaHCO3. The EtOAc layer was separated, dried over Na2SO4 and concentrated in vacuo to afford the titled intermediate (910 mg, 88%), which was used in the next step without purification. LC-MS: m/z [M+1]=386.

Provenance & Evidence