Methanol → HCID 69676501, compound

Participants

Reaction Steps

A similar procedure was used as describe for the synthesis of 2-(3,5-dichloro-phenylamino)-1-{3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-azepan-1-yl}-ethanone to afford a residue which was subjected to column chromatography (silica gel, gradient MeOH in CH2Cl2) to afford (60 mg 45%) of the titled compound. 1H NMR (DMSO-d6, 400 MHz): 11.70 and 11.62 (2s, 1H), 8.20 and 8.12 (2s, 1H), 7.18-7.06 (m, 1H), 6.64 and 6.58 (2s, 2H), 6.62 and 6.54 (2s, 1H), 6.36-6.24 (m, 2H), 4.68 and 4.62 (2s, 1H), 3.96-3.72 (m, 1H), 3.60-3.52 (m, 2H), 3.18 and 3.16 (2s, 3H), 3.14-3.12 (m, 1H), 2.70-2.64 (m, 1H), 2.14-1.98 (m, 2H), 1.92-1.52 (m, 3H), LC-MS: m/z [M+1]=445.

Provenance & Evidence