Diisopropylethylamine → HCID 86706478, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(3-amino-4-methylpiperidin-1-yl)-2-(3,5-dichlorophenylamino)ethanone (180 mg, 0.56 mmol) and 4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (192 mg, 0.62 mmol) in DMF (5 mL), was added DIEA (0.15 mL, 0.85 mmol) and the reaction mixture was stirred at 60° C. overnight. The reaction mixture was cooled to rt and diluted with EtOAc/water (1:2, 120 mL). The EtOAc layer was separated, dried over Na2SO4 and evaporated in vacuo to give a residue that was purified by column chromatography (silica gel, gradient EtOAc in hexanes) to afford the titled intermediate (120 mg, 35%). LC-MS: m/z [M+1]=587.

Provenance & Evidence