Potassium Carbonate → HCID 56970956, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(3,5-dichlorophenylamino)-1-(4-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone (0.15 g, 0.24 mmol) in MeOH (4 mL) and water (1 mL) was added K2CO3 (0.133 g, 0.96 mmol) and heated to 60° C. for 2 h. The reaction mixture was concentrated in vacuo to give a residue that was purified by column chromatography (silica gel, gradient MeOH in DCM) to give (25 mg, 23%) of the titled compound. 1H NMR (DMSO-d6, 400 MHz): δ 11.75 (s, 1H), 8.52 (s, 1H), 8.18 (s, 1H), 7.68-7.62 (m, 1H), 7.42-7.18 (4H, m), 6.71-6.56 (m, 3H), 5.19 (s, 1H), 5.06 (s, 1H), 4.23 (d, J=12 Hz, 1H) 4.12-3.94 (bs, 1H), 3.82-3.65 (m, 1H), 2.75 (m, 2H)

Provenance & Evidence