HCID 69676500, compound → HCID 69676417, compound

Participants

Reaction Steps

A similar procedure was used as described for the synthesis 2-(3,5-dichloro-phenylamino)-1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-octahydro-pyrrolo[2,3-c]pyridin-6-yl]-ethanone using (2R)-2-cyclopropyl-(3,5-dichlorophenylamino)-1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-octahydro-pyrrolo[2,3-c]pyridin-6-yl]pentan-1-one in place of 2-(3,5-dichloro-phenylamino)-1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-octahydro-pyrrolo[2,3-c]pyridin-6-yl]-ethanone. 1H NMR (400 MHz, DMSO-d6) δ=11.37 (br. s., 1H), 7.98-7.75 (m, 1H), 6.89 (br. s., 1H), 6.59-6.14 (m, 3H), 5.52 (s, 1H), 4.56-4.27 (m, 1H), 4.03 (br. s., 2H), 3.83-3.37 (m, 3H), 2.13-1.91 (m, 2H), 1.91-1.38 (m, 3H), 1.04-0.80 (m, 2H), 0.35-−0.25 (m, 4H). LC/MS (m/z): calcd. For C24H26Cl2N6O (M+1H) 485. found 485.

Provenance & Evidence