Acetic Acid → HCID 60150991, compound

Participants

Reaction Steps

A mixture of 7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester (25 mg, 0.075 mmol) and 2-morpholin-4-yl-ethylamine (0.034 mL, 0.26 mmol) in EtOH (2 mL) was refluxed for 16 h. After the mixture was cooled to r.t., AcOH (0.1 mL) and water (5 mL) were added. The resulting mixture was extracted with EtOAc, and the organic layer was dried over MgSO4 and concentrated. The crude product was purified by chromatography (0-10% MeOH/CH2Cl2) to give 18 mg of the title compound. MS: (+) m/z 434.34 (M+1).

Provenance & Evidence