反应详情

温度

140 °C

A mixture of 1-benzyl-5-hydroxy-2-oxo-3,8-diphenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid methyl ester (39 mg, 0.084 mmol), N-(2-amino-ethyl)-N-methyl-methanesulfonamide HCl salt (80 mg, 0.42 mmol), and NaOMe (23 mg, 0.42 mmol) in EtOH (3 mL) was heated at 140° C. for 6 h in a microwave reactor. Solvent was evaporated in vacuo, and the residue was partitioned between EtOAc and 0.1 M HCl. The organic layer was washed with brine and dried over MgSO4. After evaporating the solvent, the residue was purified by silica gel chromatography (10-100% EtOAc/hexanes+2% AcOH) to give 24 mg of the title compound as a light yellow solid. MS: (+) m/z 583.32 (M+1).

1. customSolvent was evaporated in vacuo
2. customthe residue was partitioned between EtOAc and 0.1 M HCl
3. washThe organic layer was washed with brine
4. dry with materialdried over MgSO4
5. customAfter evaporating the solvent
6. customthe residue was purified by silica gel chromatography (10-100% EtOAc/hexanes+2% AcOH)