HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 58155226, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid | HCID 66631842 | — |
| Reactant | HCID 66931525 | HCID 66931525 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58155226 | HCID 58155226 | — |
Reaction Steps
The hydrolysis of the (RS)-5-(5-bromo-2-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione with 6 N sodium hydroxide solution and esterification of the resulting (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid with methanol and thionylchloride yielded the (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methylester as a light yellow oil. The purity of the product allowed using it in the next step without further purification. Mass (calculated) C10H11BrFNO2 [276.107]; (found) [M+H]+=276, 278.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09273042B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-f6cdc04ba3734eee8a5ff6be8a1956a6 |
| Source note | uspto-grants-2016_03 |